Cancer researchers: Prolonged aspirin intake doubled survival in colorectal cancer

Cancer researchers: Prolonged aspirin intake doubled survival in colorectal cancer


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Colon cancer: Aspirin doubles survival
Regularly taking a low dose of aspirin can significantly increase the average survival rate for colorectal cancer. This was the result of a study by Dutch researchers, which has now been presented at the European Cancer Congress. The active ingredient could in future belong to the accompanying therapy.

Early detection of colorectal cancer can save lives
In Germany alone, around 26,000 people die of colon cancer every year. If this cancer is recognized early, it can be cured. Colorectal cancer screening can save lives, but this preventive care option is still seldom used. After the diagnosis, surgery, chemotherapy and radiation are usually the result - as is the case with other cancers. But apparently a widely used drug can also contribute to therapy: aspirin. This has now been reported by researchers from the Netherlands.

Regular intake of a low dose of aspirin
Accordingly, regular intake of a low dose of aspirin (acetylsalicylic acid / ASA) after diagnosis of gastrointestinal carcinoma can almost double the five-year survival rate. This was the result of a Dutch study with almost 14,000 patients. The results were recently presented at the European Cancer Congress in Vienna. Martine Frouws from Leiden University said, according to a news agency APA: “Aspirin was launched in 1897 as a pain reliever. Studies in the 1980s showed the effects of preventing infarction and stroke. As a result, the protective effect against cancer was also noticed in this scientific work. It has already been proven for colon cancer. ”The scientists have now examined the effect on all carcinomas of the gastrointestinal tract.

ASA for the prevention of heart attack and stroke
For the investigation, data from 13,715 patients who had been diagnosed with a corresponding disease in the Netherlands between 1998 and 2011 were evaluated. "We then linked the drug prescriptions with the data on the course of the disease," explained the study author. The focus was on the use of low-dose acetylsalicylic acid (80 to 100 milligrams per day), as prescribed by doctors, among other things, for the prevention of heart attacks and strokes. 30.5 percent of patients had taken ASA before cancer diagnosis, 8.3 percent started after, while 61.1 percent did not take aspirin. As the researchers said, the most common diagnoses concerned the large intestine (42.8 percent), the rectum (25.4 percent) and the esophagus (10.2 percent). Patients who were already taking aspirin before diagnosis were not included in the figures because the protective effect was only after the disease was diagnosed. The average observation period was 48.6 months.

ASA for accompanying routine therapy
The results were described as “striking”. "Carcinoma patients who started taking aspirin after diagnosis had a five-year survival rate of 75 percent." Without using aspirin, the five-year survival rate of patients with corresponding diseases was 42 percent, the scientist explained . Although the results suggest that acetylsalicylic acid has a strong effect in such patients, they are not sufficient for the final scientific evidence. However, another “study has been started in the Netherlands, in which patients with colon or rectal cancer are randomly assigned to a group with or taking ASA,” said Frouws. It will soon become clear whether ASA should be part of the accompanying routine therapy for these cancer patients in the future.

Protective effect of ASA proven
In recent years, a potentially lower risk of cancer from aspirin has been researched at numerous facilities worldwide. Among other things, a primary protective effect of ASA before the onset of colon cancer was demonstrated. This was mainly attributed to the anti-inflammatory effects of the substance. David Agus, professor at the University of Southern California (USC) in Los Angeles and author of numerous books, also cited this in the past. In his opinion, aspirin should protect against cancer if it is regularly taken in low doses and taken with a cholesterol inhibitor. This recommendation, however, met with a lot of criticism and extensive prevention with such drugs was strongly discouraged.

Positive effects due to the anticoagulant effect
Since the Dutch study participants were people who had been given the means to prevent cardiovascular events, they must have a different mechanism of action. The scientists believe that the positive effect of aspirin in cancer is due to its anticoagulant effect, the so-called anti-platelet effect. Platelets have the function of stopping bleeding by clumping and clogging of the vessel. It is believed that circulating tumor cells hide from the immune defense by surrounding platelets. Aspirin inhibits platelet function and thus also destroys the protection of the tumor cells from being discovered by the immune system. (ad)

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Video: Aspirin For Colon Cancer


Comments:

  1. Itzik

    Just dare to do it again!

  2. Olaf

    It went to look ...

  3. Effiom

    Very funny opinion

  4. Vudogrel

    Interesting. And most importantly, unusual.

  5. Oved

    In it something is.Thanks for the help in this question, how can I thank you?



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